Candida albicans in urine can produce testosterone: impact on the testosterone/epitestosterone sports drug test.

structure (4, 5). -NAGA deficiency is one of the rarest and probably the most heterogeneous of lysosomal storage disorders (3, 7). At present, only nine patients are known from six families. Of these, infants (four patients) and adults (five patients) display obviously different phenotypic expression. Adults commonly have angiokeratoma, loss of hearing, dizziness, and cutaneous sensory disturbance (numbness). To date, we have hesitated to diagnose the disease through the somewhat intricate procedure of TLC and electron microscopy, but the newly established method will make it easier to survey patients showing the above signs. In proposing this new method for identifying abnormal amino acid O-glycosides in urine from patients with -NAGA deficiency, we are also suggesting a way to identify compounds containing no reductive moiety excreted in the urine of patients with other lysosomal storage diseases. We thank Dr. G. Bierwirth and M. Gore for editorial assistance and Dr. Y. Hirabayashi for the kind gift of GP-D2. This research was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and by the Kodama Foundation for Research in Medical Science.